Co-op Synergy & Combo Checker
CO-OP META v2.1
MULTIPLAYER COMBO MATCHMAKER
Recommended Relic:Soul Vessel
Exhaust souls to gain infinite strength.
Slay the Spire 2 multiplayer combos
The new 4-player cooperative mode introduces Duo Legendaries—relics that only activate when specific character combinations are present in the run. Use this tool to match your team and see what cross-character combos you should aim for.
Currently, the Ironclad + Necrobinder combination is dominating the meta due to the high synergy between Soul-exhaustion and Strength-scaling.